QTL Mapping to QTL Cloning: Mice to the Rescue

QTL mapping to QTL cloning: mice to the rescue.

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R/qtl: high-throughput multiple QTL mapping

MOTIVATION R/qtl is free and powerful software for mapping and exploring quantitative trait loci (QTL). R/qtl provides a fully comprehensive range of methods for a wide range of experimental cross types. We recently added multiple QTL mapping (MQM) to R/qtl. MQM adds higher statistical power to detect and disentangle the effects of multiple linked and unlinked QTL compared with many other metho...

R/qtl: QTL Mapping in Experimental Crosses

SUMMARY R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in experimental populations derived from inbred lines. It is implemented as an add-on package for the freely-available statistical software, R, and includes functions for estimating genetic maps, identifying genotyping errors, and performing single-QTL and two-dimensional, two-QTL genome scans by ...

QTL Mapping using Diversity Outbred Mice

Beyond QTL Cloning

Natural selection sculpts phenotypes to enable adaptation to local conditions. Biologists have long been interested in the phenotypic and molecular response to selection, but we still know little about the genetic basis of adaptation. With continuing improvements in molecular technologies, we now have the tools to investigate the genes that underlie ecologically important traits. Assessing the ...